Supplementary Figure S1 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

Kanakaraju Manupati; Mingang Hao; Suhua Li; Sushma Maharjan; Jun‐Lin Guan

doi:10.1158/1541-7786.30050749

September 4, 2025

Supplementary Figure S1 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

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Key Points

Ki67+ cell presence in lung sections indicates active tumor growth due to PI3KC2β signaling.
Transplanted tumors showed differential behavior between PI3KC2β WT and KO types, highlighting the importance of this gene.
Analysis of lung sections from mice provides evidence of metastasis in breast cancer linked to mTORC1 signaling.
The findings suggest potential therapeutic targets in managing metastasis in breast cancer.

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Implication

Observational analysis shows Ki67+ cell presence in lung sections of mice with PI3KC2β KO and WT tumors, indicating mTORC1's involvement in metastasis.

Abstract

Supplementary Figure S1 shows Ki67+ cells in lung sections of recipient mice transplanted with PI3KC2β WT and KO tumor cells.

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Cite This Study

Manupati et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a06148a1 https://doi.org/10.1158/1541-7786.30050749

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Supplementary Figure S1 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

Key Points

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Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S1 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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