Supplementary Figure S4 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

Kanakaraju Manupati; Mingang Hao; Suhua Li; Sushma Maharjan; Jun‐Lin Guan

doi:10.1158/1541-7786.30050740

September 4, 2025

Supplementary Figure S4 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

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Key Points

PI3KC2β plays a critical role in mediating metastasis via mTORC1 signaling in breast cancer cells.
Key finding indicates altered levels of PI(3,4)P2 and PI(4)P in PI3KC2β WT and KO tumor cells.
Tail vein injections were performed to study lung metastasis nodules in mice, highlighting tumor behavior.
These insights suggest potential therapeutic targets for managing breast cancer metastasis.

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Implication

Supplementary figure reveals how mTORC1 signaling influences metastasis in breast cancer cells, implicating PI3KC2β.

Abstract

Supplementary Figure S4 shows PI(3,4)P2 and PI(4)P levels in PI3KC2β WT and KO tumor cells (Panels A and B) and lung metastasis nodules in recipient mice with tail vein injection of N418 cells transfected with vector control or PI3KC2β kinase-defective mutant (Panels C and D).

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Manupati et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a06148d1 https://doi.org/10.1158/1541-7786.30050740

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Supplementary Figure S4 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S4 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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