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Analysis reveals triciribine alters 4E-BP1 phosphorylation in PI3KC2β knockout cells, suggesting a role in metastasis signaling.
Supplementary Figure S3 shows AKT inhibitor triciribine reduces 4E-BP1 phosphorylation in PI3KC2β KO cells (panel A), and increased 4E-BP1 phosphorylation in PI3KC2β KO cells (Panel B).
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Manupati et al. (2025) studied this question.
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