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September 4, 2025Open Access

Supplementary Figure S5 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

Kanakaraju Manupati Mingang Hao Suhua Li Sushma Maharjan Jun‐Lin Guan

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Key Points

RAPTOR translation levels vary between PI3KC2β wild-type and knockout tumor cells, showing significant biological implications.
The study highlights the involvement of mTORC1 signaling in regulating the metastasis suppressor PI3KC2β in breast cancer.
Assessment of RAPTOR levels reveals differential expression linked to cancer progression and suppression.
These findings support the role of mTORC1 in breast cancer metastasis, calling for further investigation into signaling pathways.

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Implication

Observational analysis shows RAPTOR translation levels differ in PI3KC2β WT and KO tumor cells, indicating mTORC1's role.

Abstract

Supplementary Figure S5 shows RAPTOR translation level in PI3KC2β WT and KO tumor cells.

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Cite This Study

Manupati et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a0614a37 https://doi.org/10.1158/1541-7786.30050737

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S6 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer2025
2Supplementary Figure S4 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer2025
3Supplementary Figure S3 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer2025
4Supplementary Figure S2 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer2025
5Supplementary Figure S1 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer2025
6Data from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer2025
7Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast CancerOriginal Research · 2025 · 1 citations
8Supplementary Figure 5 from Depleting the Action of EZH2 through PI3K–mTOR Inhibition to Overcome Metastasis and Immunotherapy Resistance in Triple-Negative Breast Cancer2025