⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

September 4, 2025

Supplementary Figure S2 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

Kanakaraju Manupati Mingang Hao Suhua Li Sushma Maharjan Jun‐Lin Guan

View at Publisher

Ask AI

Bookmark

Share

Key Points

PI3KC2β overexpression enhances migration and invasion of breast cancer cells, both mouse and human.
Key evidence shows that the effects are linked to mTORC1 signaling pathways.
Observational analysis focused on mouse and human models to evaluate migration and invasion responses.
Indications suggest that targeting PI3KC2β could provide new therapeutic avenues in breast cancer treatment.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Ask your own question…

Implication

Observational analysis reveals that PI3KC2β promotes migration and invasion in breast cancer cells, indicating mTORC1 involvement.

Abstract

Supplementary Figure S2 shows effects of PI3KC2β overexpression on migration and invasion of mouse and human breast cancer cells.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Manupati et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a0614878 https://doi.org/10.1158/1541-7786.30050746

View at Publisher

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S6 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer2025
2Supplementary Figure S4 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer2025
3Supplementary Figure S1 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer2025
4Supplementary Figure S5 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer2025
5Supplementary Figure S3 from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer2025
6Data from Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer2025
7Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast CancerOriginal Research · 2025 · 2 citations
8Supplementary Figure 5 from Depleting the Action of EZH2 through PI3K–mTOR Inhibition to Overcome Metastasis and Immunotherapy Resistance in Triple-Negative Breast Cancer2025