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Differential Effect on Vasodilatation and Pain After Intradermal Capsaicin in Humans During Decay of Intravenous Regional Anesthesia With Mepivacaine

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Randomized trial shows reduced vasodilatation and capsaicin flare in arms with mepivacaine, indicating differential effects on pain responses.

Mepivacaine reduced reactive hyperemia after tourniquet release, suggesting decreased vasodilatation.
The flare area caused by capsaicin was significantly smaller in the mepivacaine-treated arm 10 minutes post-application.
No significant difference was found in mean blood flow or capsaicin-induced pain between treated and untreated arms.
Intravenous regional anesthesia did not affect the sensory function of thin afferents despite the decreased capsaicin flare.

Kalman et al. (1998) studied this question.

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Randomized trial shows reduced vasodilatation and capsaicin flare in arms with mepivacaine, indicating differential effects on pain responses.