This study demonstrates how cosolvency improves drug solubility in ibuprofen syrup formulations, suggesting its efficacy for liquid dosage forms.
The aim of the study was to formulate and evaluate ibuprofen syrup using the cosolvency technique. The cosolvency technique involves combining various water miscible solvents at low concentrations to enhance drug solubility while minimizing solvent toxicity and ensuring formulation safety. Different formulations (F1, F2, F3) were prepared using combinations of cosolvents like propylene glycol, polyethylene glycol 400, glycerol, and ethanol. The prepared formulations were evaluated for their organoleptic properties, pH, viscosity, and drug content. Formulation F1 showed the highest drug content, making it the most effective and stable formulation. The study confirms cosolvency as a practical and scalable method for producing liquid dosage forms of poorly soluble drugs.
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Chiluka et al. (2025) studied this question.
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