Conjugation of a Cyclometalated Ir(III) Complex to Human Serum Albumin for Oncosis-Mediated Photodynamic Therapy

Antonio Linero-Artiaga; Lisa-Marie Servos; Zisis Papadopoulos; Venancio Rodrı́guez; José Ruiz; Johannes Karges

doi:10.1039/d5qi01287b

January 1, 2025Inorganic Chemistry FrontiersOpen Access

Conjugation of a Cyclometalated Ir(III) Complex to Human Serum Albumin for Oncosis-Mediated Photodynamic Therapy

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Key Points

The conjugation leads to effective induction of oncosis in cancer cells, demonstrating the potential of this approach.
Photo-responsive behavior was observed, enhancing the therapeutic efficacy of the Ir(III) complex against tumors.
The innovative use of human serum albumin as a carrier may improve delivery and reduce systemic toxicity in targeted therapy.
This work establishes a foundation for further exploration of metallodrug systems in combination with albumin for cancer treatment.

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Implication

This novel metallodrug–albumin conjugate demonstrates effective oncosis induction in cancer cells, suggesting an innovative approach to photodynamic therapy.

Abstract

We report on the first photo-responsive metallodrug–albumin conjugate capable of inducing oncosis in cancer cells.

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Linero-Artiaga et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad6a54b1d3bfb60e5cf3 https://doi.org/10.1039/d5qi01287b

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Conjugation of a Cyclometalated Ir(III) Complex to Human Serum Albumin for Oncosis-Mediated Photodynamic Therapy

Key Points

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Implication

Abstract

Discussion

Cite This Study

Conjugation of a Cyclometalated Ir(III) Complex to Human Serum Albumin for Oncosis-Mediated Photodynamic Therapy

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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