Figure S2 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells

This is a Cohort Study study (also classified as: Experimental Study).

Key Points

MCU knockdown significantly reduces glioblastoma stem cell viability, impacting tumor growth.
In xenograft models, tumor growth is suppressed following MCU knockdown, indicating a critical role for mitochondrial calcium.
The study identifies acetyl-CoA metabolism as linked to H3K27 acetylation, essential for maintaining glioblastoma stem cells.
The findings highlight a connection between mitochondrial function and cancer stem cell biology in glioblastoma.

Figure S2 demonstrates that MCU knockdown decreases GSC viability and tumor growth in xenograft models, suggesting potential therapeutic targets.

Figure S2 shows that MCU knockdown selectively impairs GSC viability and suppresses tumor growth in orthotopic xenograft models.

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Liu et al. (2025) studied this question.

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