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September 15, 2025

Figure S3 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells

Guangqin Liu Haoqian Zhang Siqi Chen Jun Gao Haixin Zhao Yan Dong Changwei Liu Xuechen Wei Ting Li Chang Lu Hai-Zhen Zhu Dingyi Lu Shiyu Feng Teng Li Weina Zhang Qing Xia Jianghong Man Tao Zhou Jiayi Chen Ailing Li Xin Pan

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Key Points

MCU regulates acetyl-CoA production in glioblastoma stem cells, indicating its critical role in metabolism.
The connection between acetyl-CoA and H3K27 acetylation may be essential for maintaining stemness in glioblastoma cells.
Alterations in MCU function could have implications for targeted therapies in glioblastoma treatment.
Understanding these mechanisms can enhance strategies for combating glioblastoma stem cell resilience.

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Implication

Analysis reveals MCU's impact on acetyl-CoA and H3K27 acetylation in glioblastoma stem cells, suggesting regulatory functions.

Abstract

Figure S3 shows that MCU regulates acetyl-CoA production in GSCs.

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Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d4508931b076d99fa588ae https://doi.org/10.1158/0008-5472.30125833

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S1 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025
2Figure S4 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025
3Figure S5 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025
4Figure S2 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025
5Data from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025

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Figure S6 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025
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