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September 15, 2025

Figure S4 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells

Guangqin Liu Haoqian Zhang Siqi Chen Jun Gao Haixin Zhao Yan Dong Changwei Liu Xuechen Wei Ting Li Chang Lu Hai-Zhen Zhu Dingyi Lu Shiyu Feng Teng Li Weina Zhang Qing Xia Jianghong Man Tao Zhou Jiayi Chen Ailing Li Xin Pan

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Key Points

MCU-dependent H3K27 acetylation is crucial for glioblastoma stem cell growth and survival.
The findings highlight an essential metabolic linkage between mitochondrial function and glioblastoma stem cells.
This study emphasizes the role of acetyl-CoA metabolism in maintaining the stemness of glioblastoma cells.
Realizing the importance of H3K27 acetylation could lead to novel therapeutic targets for glioblastoma.

Implication

Observational analysis shows H3K27 acetylation is vital for glioblastoma stem cell growth, suggesting links to acetyl-CoA metabolism.

Abstract

Figure S4 shows that MCU-dependent H3K27 acetylation is essential for GSC growth and survival.

Discussion

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Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d4508931b076d99fa588b0 https://doi.org/10.1158/0008-5472.30125827

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S3 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025
2Figure S1 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025
3Figure S2 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025
4Figure S5 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025
5Data from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025

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