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September 15, 2025

Figure S5 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells

Guangqin Liu Haoqian Zhang Siqi Chen Jun Gao Haixin Zhao Yan Dong Changwei Liu Xuechen Wei Ting Li Chang Lu Hai-Zhen Zhu Dingyi Lu Shiyu Feng Teng Li Weina Zhang Qing Xia Jianghong Man Tao Zhou Jiayi Chen Ailing Li Xin Pan

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Key Points

MCU regulates TRIB3 expression in glioblastoma stem cells, supporting its role in acetylation processes.
The results highlight the connection between acetyl-CoA metabolism and H3K27 acetylation in maintaining stemness.
This research focuses on how mitochondrial functions influence glioblastoma stem cell survival and characteristics.
Understanding the pathways connecting MCU and acetylation may reveal new therapeutic targets for glioblastoma treatment.

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Implication

Analysis reveals that MCU regulates TRIB3 expression in glioblastoma stem cells, suggesting metabolic links.

Abstract

Figure S5 shows that MCU regulates TRIB3 expression in GSCs

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Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d4508931b076d99fa588a1 https://doi.org/10.1158/0008-5472.30125824

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S3 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025
2Figure S1 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025
3Figure S4 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025
4Figure S2 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025
5Data from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025

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Figure S6 from Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylation to Maintain Glioblastoma Stem Cells2025
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