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September 15, 2025

Supplementary Figure S6 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma

Fengqi Zhou Yuanyuan Sun Xinhua Chen Di Wu Zhennan Tao Lingyun Wu Gao Chen Xiangyu Liu Tianfu Yu

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Key Points

R-2HG inhibits proliferation in IDH1 wild-type glioma cells, presenting a promising therapeutic avenue.
Ubiquitination dynamics, particularly via UBE2T, could significantly affect nucleolar function and tumor progression.
Mutations in IDH1 and TP53 are critical in defining glioma behavior, making their study essential.
Further exploration of these molecular interactions could inform targeted treatment strategies for glioma.

Implication

Supplementary analysis shows R-2HG reduces proliferation in IDH1 wild-type glioma cells, indicating its potential impact.

Abstract

Supplementary Figure S6: R-2HG inhibits the proliferation of IDH1 wild-type glioma cells.

Discussion

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Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68d4538731b076d99fa58929 https://doi.org/10.1158/1078-0432.30125679

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S3 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
2Supplementary Figure S2 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
3Supplementary Figure S7 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
4Supplementary Figure S4 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
5Supplementary Figure S5 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025