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September 15, 2025

Supplementary Figure S5 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma

Fengqi Zhou Yuanyuan Sun Xinhua Chen Di Wu Zhennan Tao Lingyun Wu Gao Chen Xiangyu Liu Tianfu Yu

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Key Points

UBE2T-mediated ubiquitination enhances nucleolar function in glioma cells, promoting tumor progression.
Key evidence indicates the role of E3 ubiquitin ligases in UBE2T interactions, influencing glioma characteristics.
The study employs experimental analysis of UBE2T and its E3 ligases in mutant glioma models to draw conclusions.
Findings highlight a potential therapeutic target in UBE2T for IDH1/TP53-mutant glioma treatments.

Implication

Investigating UBE2T interactions with E3 ubiquitin ligases in glioma, suggesting enhanced nucleolar activity.

Abstract

Supplementary Figure S5: Expression and distribution of putative UBE2T interacting E3 ubiquitin ligases.

Discussion

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Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68d4538731b076d99fa5895c https://doi.org/10.1158/1078-0432.30125682

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S3 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
2Supplementary Figure S2 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
3Supplementary Figure S7 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
4Supplementary Figure S6 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
5Supplementary Figure S4 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025