Supplementary Figure S1 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma

Fengqi Zhou; Yuanyuan Sun; Xinhua Chen; Di Wu; Zhennan Tao; Lingyun Wu; Gao Chen; Xiangyu Liu; Tianfu Yu

doi:10.1158/1078-0432.30125694

September 15, 2025Open Access

Supplementary Figure S1 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma

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Key Points

UBE2T-mediated ubiquitination enhances nucleolar function, promoting glioma progression.
Validation of knock-down efficiency was demonstrated in GBM30 cells with significant impact on nucleolar functions.
Analysis focused on IDH1/TP53-mutant glioma, highlighting the unique cellular dynamics at play.
Findings suggest potential therapeutic targets in the ubiquitin pathway for glioma treatment.

Implication

Supplementary figure shows the impact of UBE2T on nucleolar function in IDH1/TP53-mutant glioma, suggesting significant implications for tumor progression.

Abstract

Supplementary Figure S1: GBM30 cell information and knock-down efficiency validation.

Discussion

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Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68d4538731b076d99fa5893a https://doi.org/10.1158/1078-0432.30125694

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Supplementary Figure S1 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S1 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma

Key Points

Implication

Abstract

Discussion

Cite This Study

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