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September 15, 2025

Supplementary Figure S7 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma

Fengqi Zhou Yuanyuan Sun Xinhua Chen Di Wu Zhennan Tao Lingyun Wu Gao Chen Xiangyu Liu Tianfu Yu

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Key Points

UBE2T-mediated ubiquitination significantly enhances nucleolar function in IDH1/TP53-mutant glioma, promoting progression.
Key evidence shows that alterations in UBE2T activity directly affect nucleolar function linked to glioma progression.
The method involved in vivo and in vitro experiments to examine the roles of UBE2T and HP1α in glioma.
This research highlights UBE2T as a critical regulator in glioma, potentially guiding future therapeutic strategies.

Implication

Supplementary details reveal how UBE2T enhances nucleolar function, promoting cancer progression through IDH1 and TP53 mutations.

Abstract

Supplementary Figure S7: Supplementary materials for in vivo and in vitro experiments of Figure 6 in main text.

Discussion

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Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68d4538731b076d99fa589eb https://doi.org/10.1158/1078-0432.30125676

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S2 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
2Supplementary Figure S3 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
3Supplementary Figure S6 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
4Supplementary Figure S4 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
5Supplementary Figure S5 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025