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September 15, 2025

Supplementary Figure S3 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma

Fengqi Zhou Yuanyuan Sun Xinhua Chen Di Wu Zhennan Tao Lingyun Wu Gao Chen Xiangyu Liu Tianfu Yu

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Key Points

UBE2T significantly enhances nucleolar function, contributing to glioma progression.
The study shows that UBE2T also facilitates the growth and stem-like properties of glioma cells.
Nuclear functions related to UBE2T are critical in the context of IDH1 and TP53 mutations in glioma.
Investigating UBE2T's role could uncover new therapeutic targets in glioma treatment.

Implication

UBE2T promotes growth and stem-like properties in glioma cells, indicating its role in tumor progression.

Abstract

Supplementary Figure S3: UBE2T facilitates the growth and stem-like properties of glioma cells.

Discussion

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Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68d4538731b076d99fa589e5 https://doi.org/10.1158/1078-0432.30125688

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1Supplementary Figure S6 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
2Supplementary Figure S2 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
3Supplementary Figure S5 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
4Supplementary Figure S7 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
5Supplementary Figure S4 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025