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September 15, 2025

Supplementary Figure S2 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma

Fengqi Zhou Yuanyuan Sun Xinhua Chen Di Wu Zhennan Tao Lingyun Wu Gao Chen Xiangyu Liu Tianfu Yu

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Key Points

UBE2T-mediated ubiquitination enhances nucleolar function in IDH1/TP53-mutant glioma, driving tumor progression.
Analysis of datasets shows UBE2T's role in glioma pathology, highlighting its potential as a therapeutic target.
Investigations utilize tissue samples and public glioma databases, providing comprehensive insights into molecular mechanisms.
These findings suggest that targeting UBE2T could be significant in treatment strategies for glioma.

Implication

Analysis reveals UBE2T impacts nucleolar function in IDH1/TP53-mutant glioma, suggesting potential therapeutic targets.

Abstract

Supplementary Figure S2: Supplementary data on glioma public databases and tissue samples.

Discussion

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Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68d4538731b076d99fa58965 https://doi.org/10.1158/1078-0432.30125691

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S3 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
2Supplementary Figure S7 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
3Supplementary Figure S6 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
4Supplementary Figure S4 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025
5Supplementary Figure S5 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma2025