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September 25, 2025Open Access

Figure S2 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Asael Roichman Gabriela Reyes‐Castellanos Ziqing Chen Zihong Chen Sarah J. Mitchell Michael R. MacArthur Akshada Sawant Llewelyn Levett Jesse R. Powers Victoria Burgo Maria Gomez-Jenkins Maria Ibrahim Xincheng Xu Beianka Tomlinson Xiang Hang Eric G. Pamer Yong Wei Yibin Kang Eileen White Joshua D. Rabinowitz

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Key Points

Dietary fiber lacks a consistent effect on immune checkpoint blockade efficacy in various murine tumor models, suggesting variability.
Extended microbiome analysis reveals that different diets may influence immune responses in tumor treatments.
The findings suggest that dietary fiber's role in cancer therapy could be context-dependent in these murine models.
Further research is needed to establish clear relationships between dietary components and immune checkpoint effectiveness.

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Implication

Analysis shows inconsistent effects of dietary fiber on immune checkpoint blockade efficacy, highlighting murine tumor models.

Abstract

Extended microbiome analysis of mice on the different diets

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Cite This Study

Roichman et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3ddeebfec0fc52366e0 https://doi.org/10.1158/0008-5472.30210071

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S3 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025
2Table S4 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025
3Table S4 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025
4Table S4 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025
5Table S10 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025

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Table S11 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025
Table S2 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025
Table S2 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models2025