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October 1, 2025Nutrition JournalOpen Access

Clinical randomized trial of vitamin D and C supplementation in critically ill patients with respiratory failure

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Authors

AVAynaz VelayatiMVMohammadreza VafaMYMahdi Yadollahzadeh

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Overview

Randomized trial assessed vitamin D and C's impact on inflammation and clinical outcomes in ICU patients, indicating potential benefits.

Key Points

  • Vitamin D and C supplementation significantly improved inflammation and oxidative status in critically ill patients.
  • At the trial's conclusion, hs-CRP and IL-6 levels decreased significantly in the intervention group (p < 0.001).
  • This double-blind, randomized, placebo-controlled trial included 34 patients in the intervention group and 33 in the control group.
  • Improved inflammation may lead to shorter ICU stays, but supplementation did not significantly affect 90-day mortality rates.

Cite This Study

Velayati et al. (2025) studied this question.

synapsesocial.com/papers/68dd91c7fe798ba2fc49828fhttps://doi.org/10.1186/s12937-025-01214-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vitamin D Supplementation in Critically Ill Patients: A Meta-Analysis of Randomized Controlled Trials2022 · 18 citations
  2. 2Vitamin D supplementation and the outcomes of critically ill adult patients: a systematic review and meta-analysis of randomized controlled trials2020 · 55 citations
  3. 3Vitamin C deficiency and its effect as adjuvant therapy in sepsis patients2026
  4. 4Vitamin D supplementation may be beneficial in improving the prognosis of patients with chronic obstructive pulmonary disease in the intensive care unit: a retrospective study2024 · 5 citations
  5. 5Vitamin C Supplementation During Intensive Care Unit Stay Is Associated With Improved Outcomes in Critically Ill Patients With Sepsis‐Induced Coagulopathy: A Cohort Study2025