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October 1, 2025Open Access

Table S1 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration

Rui Zhou Lu Han Jing Wang Ling Ma Tingting Zhang Tianming Qi Meichen Liu Yijie Dong Weiguo Zhang Shan Cen

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Key Points

Lipid nanoparticles effectively deliver mRNAs, leading to increased T-cell infiltration in cancer cells.
The formulation of ELANE and PPE results in targeted delivery and selective toxicity towards tumor cells.
Using cancer models, significant enhancement of immune response was observed with this approach, demonstrating its potential.
The findings support further development of this method for targeted cancer therapies and immunotherapy strategies.

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Implication

Lipid nanoparticles deliver mRNAs encoding toxin proteins, enhancing T-cell response in cancer cells.

Abstract

LNP formulation of ELANE and PPE.

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Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21924 https://doi.org/10.1158/0008-5472.30255773

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1Figure S4 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
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3Figure S7 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
4Figure S1 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
5Figure S5 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025