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October 1, 2025

Figure S2 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration

Rui Zhou Lu Han Jing Wang Ling Ma Tingting Zhang Tianming Qi Meichen Liu Yijie Dong Weiguo Zhang Shan Cen

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Key Points

Lipid nanoparticle-encapsulated mRNAs enhance T-cell infiltration into cancer cells, improving targeting.
Key evidence reveals significant modulation of BAX and BCL2L1 expression levels due to secreted ELANE.
Experimental study utilized lipid nanoparticles containing mRNAs to assess the impact on cancer cell targeting.
Findings suggest potential therapeutic benefits for selective targeting of cancer through T-cell activation.

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Implication

Analysis shows that mRNA in lipid nanoparticles targets cancer cells, enhancing T-cell infiltration.

Abstract

The effects of secreted ELANE on expression levels of BAX and BCL2L1.

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Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2194e https://doi.org/10.1158/0008-5472.30255794

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Keep reading

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1Figure S1 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
2Figure S7 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
3Figure S5 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
4Figure S4 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
5Figure S3 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025