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October 1, 2025Open Access

Figure S5 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration

Rui Zhou Lu Han Jing Wang Ling Ma Tingting Zhang Tianming Qi Meichen Liu Yijie Dong Weiguo Zhang Shan Cen

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Key Points

Lipid nanoparticles delivering mRNA encoding tumor-specific toxins successfully increased T-cell infiltration.
Treatment demonstrated significant effects on immune cell frequencies in mice, highlighting its potential effectiveness.
Assessment using lipid nanoparticle technology and mRNA suggests a novel strategy for cancer immunotherapy.
These findings support the use of mRNA-based treatments to selectively target cancer cells and improve immune responses.

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Implication

This analysis shows that lipid nanoparticle-encapsulated mRNA increases T-cell infiltration in tumors, indicating enhanced immunity.

Abstract

The frequencies of other types of immune cells in ELANE mRNA-LNP treated mice.

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Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21934 https://doi.org/10.1158/0008-5472.30255785

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S4 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
2Figure S7 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
3Figure S3 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
4Figure S1 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
5Table S1 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025