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October 1, 2025Open Access

Figure S4 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration

Rui Zhou Lu Han Jing Wang Ling Ma Tingting Zhang Tianming Qi Meichen Liu Yijie Dong Weiguo Zhang Shan Cen

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Key Points

The study shows that lipid nanoparticle-encapsulated mRNAs effectively induce CD8+ T cell infiltration into tumor sites.
Notable changes were observed in T-cell levels with an increase in CD8+ T cells due to the mRNA of ELANE and PPE.
Lipid nanoparticles were utilized for efficient delivery of mRNAs to specifically target cancer cells and stimulate immune response.
The findings imply a promising approach to enhance T-cell responses in cancer, paving the way for potential therapies.

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Implication

Lipid nanoparticle-based mRNAs encoding tumor-specific toxins induce CD8+ T cells infiltration, suggesting a novel cancer therapeutic strategy.

Abstract

LNP-enveloped mRNA of ELANE and PPE induce CD8+ T cells infiltration.

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Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21939 https://doi.org/10.1158/0008-5472.30255788

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1Figure S3 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
2Table S1 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
3Figure S1 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
4Figure S5 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
5Figure S7 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025