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October 1, 2025Open Access

Figure S3 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration

Rui Zhou Lu Han Jing Wang Ling Ma Tingting Zhang Tianming Qi Meichen Liu Yijie Dong Weiguo Zhang Shan Cen

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Key Points

Lipid nanoparticle-encapsulated mRNA reduces breast tumor growth, demonstrating significant anti-tumor effects.
The study shows enhancement in T-cell infiltration associated with mRNA delivery, suggesting improved immune response.
Analysis involved lipid nanoparticle formulations to assess their efficacy in targeting cancer cells in vitro and in vivo.
Findings emphasize the therapeutic potential of T-cell activation in cancer treatment, highlighting a novel treatment approach.

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Implication

Lipid nanoparticles deliver mRNA encoding tumor-specific toxins, improving T-cell infiltration and cancer control.

Abstract

LNP-enveloped mRNA of ELANE and PPE attenuate breast tumor growth.

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Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2193f https://doi.org/10.1158/0008-5472.30255791

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1Figure S4 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
2Table S1 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
3Figure S7 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
4Figure S1 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025
5Figure S5 from Lipid Nanoparticle–Encapsulated mRNAs Encoding Tumor-Specific Toxin Proteins Selectively Target Cancer Cells and Stimulate T-cell Infiltration2025