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October 1, 2025

Supplementary Figure 7 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4⁺ T Cells

Signe Caksa Timothy J. Purwin Dan A. Erkes Kristen M. DeRosa Erica Kitterman Samantha M. Barnada Casey D. Stefanski Haley P. Wilson Glenn L. Mersky McKenna Q. Glasheen Jacob S. Heilizer Namra Ajmal Yunguang Sun Joanna Chan Hallgeir Rui Inna Chervoneva Claudia Capparelli Andrew E. Aplin

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Key Points

Elevated transglutaminase-2 promotes tumor formation in SOX10-deficient melanoma models, reducing immune response.
Flow cytometry analysis reveals significant decreases in intratumoral CD4+ T cells in TGM2-overexpressing tumors.
Representative gating strategy for YUMMER1.7-EV displayed notable tumor characteristics and immune alterations.
Understanding TGM2's role may unveil targets for enhancing tumor immunity in melanoma patients.

Implication

Analysis of tumor onset and CD4+ T cell reduction in SOX10-deficient melanoma models identifies critical mechanisms.

Abstract

Representative gating strategy for YUMMER1.7-EV and TGM2-overexpressing tumors analyzed by flow cytometry

Discussion

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Cite This Study

Caksa et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21973 https://doi.org/10.1158/0008-5472.30255545

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 1 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025
2Supplementary Figure 6 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025
3Supplementary Figure 5 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025
4Supplementary Figure 3 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025
5Supplementary Figure 4 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025