Supplementary Figure 4 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4⁺ T Cells

Signe Caksa; Timothy J. Purwin; Dan A. Erkes; Kristen M. DeRosa; Erica Kitterman; Samantha M. Barnada; Casey D. Stefanski; Haley P. Wilson; Glenn L. Mersky; McKenna Q. Glasheen; Jacob S. Heilizer; Namra Ajmal; Yunguang Sun; Joanna Chan; Hallgeir Rui; Inna Chervoneva; Claudia Capparelli; Andrew E. Aplin

doi:10.1158/0008-5472.30255554

October 1, 2025

Supplementary Figure 4 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4⁺ T Cells

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Key Points

Transglutaminase-2 knockdown does not influence the growth of melanoma cells lacking SOX10, indicating a complex tumor behavior.
The study suggests a decrease in intratumoral CD4 T cells, pointing to alterations in the immune response within the tumor microenvironment.
Findings reveal a potential avenue for therapeutic exploration in melanoma characterized by SOX10 deficiency, emphasizing the importance of immune interactions.
Understanding the role of transglutaminase-2 may provide insights into tumor onset mechanisms and the modulation of immune cell populations.

Implication

Analysis reveals that transglutaminase-2 does not alter SOX10-deficient melanoma growth, suggesting distinct tumor biology and immune landscape changes.

Abstract

TGM2 knockdown does not change the growth or invasiveness of SOX10-knockout cells

Discussion

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Cite This Study

Caksa et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2199e https://doi.org/10.1158/0008-5472.30255554

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Supplementary Figure 4 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4⁺ T Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 4 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4⁺ T Cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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