⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

October 1, 2025Open Access

Supplementary Figure 3 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4⁺ T Cells

Signe Caksa Timothy J. Purwin Dan A. Erkes Kristen M. DeRosa Erica Kitterman Samantha M. Barnada Casey D. Stefanski Haley P. Wilson Glenn L. Mersky McKenna Q. Glasheen Jacob S. Heilizer Namra Ajmal Yunguang Sun Joanna Chan Hallgeir Rui Inna Chervoneva Claudia Capparelli Andrew E. Aplin

View Full Paper

Ask AI

Bookmark

Share

Key Points

Elevated transglutaminase-2 promotes tumor onset in melanoma, decreasing intratumoral CD4 T cells.
Key evidence indicates the presence of transglutaminase-2 is associated with reduced CD4 T cell counts.
The approach includes an analysis of the TGM2 promoter binding by BRD4 in melanoma samples.
These findings highlight the potential role of transglutaminase-2 in tumor immunity and development.

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

Analysis reveals elevated transglutaminase-2 promotes tumor formation in SOX10-deficient melanoma, decreasing CD4 T Cells.

Abstract

BRD4 binds to the TGM2 promoter

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Caksa et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2199d https://doi.org/10.1158/0008-5472.30255557

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 1 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025
2Supplementary Figure 6 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025
3Supplementary Figure 5 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025
4Supplementary Figure 4 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025
5Supplementary Figure 7 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025