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October 1, 2025

Supplementary Figure 6 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4⁺ T Cells

Signe Caksa Timothy J. Purwin Dan A. Erkes Kristen M. DeRosa Erica Kitterman Samantha M. Barnada Casey D. Stefanski Haley P. Wilson Glenn L. Mersky McKenna Q. Glasheen Jacob S. Heilizer Namra Ajmal Yunguang Sun Joanna Chan Hallgeir Rui Inna Chervoneva Claudia Capparelli Andrew E. Aplin

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Key Points

TGM2 overexpression promotes tumor onset in immunocompetent mice, decreasing cd4+ T cell presence.
The presence of tgm2 alters tumor development, though it does not affect 3D spheroid growth significantly.
Experimental analysis using immunocompetent mouse models helps illuminate tumor biology in melanoma.
Findings emphasize the potential role of tgm2 in immune modulation during tumor initiation.

Implication

Overexpression of tgm2 reduces intratumoral cd4+ T cells in melanoma, suggesting roles in tumor onset.

Abstract

TGM2 overexpression modulates tumor onset in immunocompetent mice, but does not affect 3D spheroid growth

Discussion

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Cite This Study

Caksa et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a219ca https://doi.org/10.1158/0008-5472.30255548

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 4 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025
2Supplementary Figure 1 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025
3Supplementary Figure 5 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025
4Supplementary Figure 3 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025
5Supplementary Figure 7 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4<sup>+</sup> T Cells2025