Supplementary Figure 1 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4⁺ T Cells

Signe Caksa; Timothy J. Purwin; Dan A. Erkes; Kristen M. DeRosa; Erica Kitterman; Samantha M. Barnada; Casey D. Stefanski; Haley P. Wilson; Glenn L. Mersky; McKenna Q. Glasheen; Jacob S. Heilizer; Namra Ajmal; Yunguang Sun; Joanna Chan; Hallgeir Rui; Inna Chervoneva; Claudia Capparelli; Andrew E. Aplin

doi:10.1158/0008-5472.30255563

October 1, 2025

Supplementary Figure 1 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4⁺ T Cells

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Key Points

Increased transglutaminase-2 correlates with tumor onset in melanoma, potentially impacting progression.
SOX10-deficient melanoma shows significant upregulation of transglutaminase-2 and reduced CD4 T Cells, indicating immune evasion.
The study suggests a crucial link between transglutaminase-2 expression and immune cell presence in melanoma.
Findings highlight the role of transglutaminase-2 in tumor biology and its potential implications for treatment strategies.

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Implication

Observational analysis reveals increased transglutaminase-2 levels correlating with decreased CD4 T Cells in melanoma, indicating a potential barrier to immune response.

Abstract

TGM2 is upregulated following SOX10 knockout

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Cite This Study

Caksa et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a7c https://doi.org/10.1158/0008-5472.30255563

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Supplementary Figure 1 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4⁺ T Cells

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 1 from Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4⁺ T Cells

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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