Figure 2 from Functional Analysis of Rare RAS Variants of Unknown Significance

Lollipop chart and transforming activity of RAS variants. A, The results of the FFA for each RAS isoform are shown in the lollipop chart. The circle color indicates FFA scores, and the frame color of the circles indicates mutation type. The size of the circles was proportional to COSMIC count. B, The triplicate data of a representative variant in the FFA. C, Correlation of the FFA score of RAS variants with the variant count in the public databases or the OncoKB annotation. The oncogenicity evaluated as the FFA score is shown in colors and compared with the variant count number in the COSMIC, C-CAT, and GENIE databases. The distribution of FFA scores compared with OncoKB annotation is shown in the pie chart.