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October 2, 2025Open Access

Supplementary Figure S4 from Functional Analysis of Rare RAS Variants of Unknown Significance

Soohwan Park Masachika Ikegami Rina Kitada Kazuya Takamochi Kenji Suzuki Hiroyuki Mano Shinji Kohsaka

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Key Points

Transforming activity of rare NRAS variants is demonstrated, indicating their potential role in cancer.
Key evidence reveals specific NRAS variants showing significant transforming activity during analysis.
The methodology employed is a functional analysis examining the effects of NRAS variants on cellular activities.
These findings highlight the need for further investigation into the mechanisms of NRAS variants in cancer.

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Implication

Analysis demonstrates transforming activity of rare NRAS variants, suggesting potential implications in cancer biology.

Abstract

Transforming activity of NRAS variants

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Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/68de6f3f83cbc991d0a22d42 https://doi.org/10.1158/2767-9764.30261473

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S1 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
2Supplementary Figure S2 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
3Supplementary Figure S6 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
4Supplementary Figure S7 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
5Supplementary Figure S9 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025