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October 2, 2025Open Access

Supplementary Figure S9 from Functional Analysis of Rare RAS Variants of Unknown Significance

Soohwan Park Masachika Ikegami Rina Kitada Kazuya Takamochi Kenji Suzuki Hiroyuki Mano Shinji Kohsaka

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Key Points

Immunoblot analysis indicates significant changes in KRAS variants under BI-2865 treatment in 3T3 cells, highlighting the impact of specific mutations.
The study identifies how different KRAS variants respond to the treatment, with potential therapeutic implications for RAS-related diseases.
Assessment using immunoblot analysis across multiple KRAS variants in treated 3T3 cells provides insights into their functional significance.
Understanding RAS variants may enhance targeted therapies, though further investigation is necessary to translate findings to clinical settings.

Implication

Immunoblot analysis reveals effects of KRAS variants in 3T3 cells treated with BI-2865, suggesting implications for RAS variant research.

Abstract

Immunoblot analysis of KRAS variants in 3T3 cells treated with BI-2865

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Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/68de6f3f83cbc991d0a22d28 https://doi.org/10.1158/2767-9764.30261458

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S7 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
2Figure 3 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
3Supplementary Figure S8 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
4Supplementary Figure S4 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
5Supplementary Figure S1 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025