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October 2, 2025Open Access

Supplementary Figure S8 from Functional Analysis of Rare RAS Variants of Unknown Significance

Soohwan Park Masachika Ikegami Rina Kitada Kazuya Takamochi Kenji Suzuki Hiroyuki Mano Shinji Kohsaka

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Key Points

Sensitivity to a pan-KRAS inhibitor was effectively assessed using the MANO method and PrestoBlue assay.
The study demonstrates concordance in the results obtained through both methods for RAS variants.
These assays provide valuable insights into the functional significance of rare RAS variants of unknown significance.
Findings support the potential for using these methodologies in evaluating drug responses in functional analyses.

Implication

Functional analysis reveals concordance in sensitivity to KRAS inhibitors using MANO and PrestoBlue assay methods.

Abstract

Concordance in the sensitivity to pan-KRAS inhibitor assessed through the MANO method and PrestoBlue cell viability assay

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Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/68de6f3f83cbc991d0a22d29 https://doi.org/10.1158/2767-9764.30261461

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S7 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
2Supplementary Figure S9 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
3Supplementary Figure S2 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
4Supplementary Figure S1 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
5Figure 3 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025