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October 2, 2025Open Access

Supplementary Figure S6 from Functional Analysis of Rare RAS Variants of Unknown Significance

Soohwan Park Masachika Ikegami Rina Kitada Kazuya Takamochi Kenji Suzuki Hiroyuki Mano Shinji Kohsaka

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Key Points

FFA scores demonstrate significant concordance between KRAS and its HRAS/NRAS variants, indicating similarity in functional impact.
Functional analysis includes comparative measurement of FFA scores, highlighting the potential biological relevance of RAS variants.
The study explores variations in RAS genes, specifically KRAS, HRAS, and NRAS, contributing to understanding their roles in signaling pathways.
Findings indicate that understanding RAS variants may lead to better insights into their clinical significance and implications.

Implication

Analysis shows concordance of FFA scores between KRAS and corresponding HRAS/NRAS variants, suggesting a potential linkage.

Abstract

Concordance of FFA scores between KRAS and corresponding HRAS/NRAS variants

Discussion

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Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/68de6f3f83cbc991d0a22d23 https://doi.org/10.1158/2767-9764.30261467

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S4 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
2Supplementary Figure S1 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
3Supplementary Figure S2 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
4Figure 2 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025
5Supplementary Figure S7 from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance2025