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September 8, 2024ChemMedChemOpen Access

Development of Integrin Targeting Chimeras (ITACs) for the Lysosomal Degradation of Extracellular Proteins

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Authors

YZYaxian ZhouYLYaxian LiaoYZYuan Zhao

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Zhou et al. (2024) studied this question.

synapsesocial.com/papers/68e590f7b6db64358752ca4bhttps://doi.org/10.1002/cmdc.202300643
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lysosome‐Targeting Chimeras (LYTACs): From Modular Design Principles to Diverse Therapeutic Applications2026 · 1 citations
  2. 2Development of Integrin-Facilitated Bispecific Aptamer Chimeras for Membrane Protein Degradation2024 · 47 citations
  3. 3Applications of Lysosome‐Targeting Receptors (LTRs) in Targeted Protein Degradation2025
  4. 4Lysosome‐Mediated Targeted Protein Degradation: Emerging Chimeric Platforms for Extracellular and Intracellular Therapeutics2025
  5. 5Polymeric Lysosomal-Targeting Chimeras: Extracellular Targeted Protein Degradation Without Co-opting Lysosome-Targeting Receptors2024 · 1 citations