The current study outlines two cases of Acute Disseminated Encephalomyelitis (ADEM) occurring in two children who received a rabies vaccine. The patients, aged 10 and 8 respectively, developed anarchic neurological symptoms after vaccination, confirming the diagnosis of ADEM through brain MRI. In the first case, bilateral abnormalities were observed in several regions, while in the second case, bilateral abnormalities of the occipital and parietal subcortical white matter were detected. Treatment included intravenous corticosteroid therapy and plasma exchange. Although slight clinical improvement was observed, neurological symptoms persisted.
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Elmazi et al. (2024) studied this question.
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