Figure S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m⁶A Methylation to Stabilize PARP1 mRNA

Zhaochang Qi; Lifang He; Zemei Xu; Xi Luo; Likeng Ji; Chuqi Lin; Armando E. Giuliano; Xiaojiang Cui; Zihao Deng; Jundong Wu; Stanley L. Lin; Yu Cui

doi:10.1158/0008-5472.30363409

October 15, 2025

Figure S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m⁶A Methylation to Stabilize PARP1 mRNA

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Key Points

Knockdown of PCBP2 increases sensitivity to olaparib in breast cancer cells, enhancing treatment effectiveness.
In vitro and in vivo evidence demonstrates that inhibition of m6A methylation stabilizes PARP1 mRNA, promoting drug resistance.
Observational analysis supports the role of m6A methylation in regulating PARP1, a key player in breast cancer cell survival.
Findings suggest that targeting PCBP2 may improve responses to olaparib in resistant breast cancer populations.

Implication

Supplementary material shows how knockdown of PCBP2 enhances olaparib sensitivity in breast cancer cells, implying therapeutic implications.

Abstract

Supplementary Figure S2 supports the Results section titled "Stable knockdown of PCBP2 enhances olaparib sensitivity in olaparib-resistant breast cancer cells both in vitro and in vivo".

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Cite This Study

Qi et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcab9 https://doi.org/10.1158/0008-5472.30363409

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Figure S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m⁶A Methylation to Stabilize PARP1 mRNA

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m⁶A Methylation to Stabilize PARP1 mRNA

Key Points

Implication

Abstract

Discussion

Cite This Study

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