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October 15, 2025

Table S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m⁶A Methylation to Stabilize PARP1 mRNA

Zhaochang Qi Lifang He Zemei Xu Xi Luo Likeng Ji Chuqi Lin Armando E. Giuliano Xiaojiang Cui Zihao Deng Jundong Wu Stanley L. Lin Yu Cui

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Key Points

PCBP2 inhibits m6A methylation affecting PARP1 mRNA, leading to olaparib resistance in breast cancer.
Research indicates that PCBP2's action stabilizes PARP1 mRNA, contributing to cancer treatment evasion in specific cellular contexts.
The study employed targeted RNA methylation techniques to investigate the relationship between methylation and PARP1 levels.
Findings support the significance of m6A methylation pathways in drug resistance, highlighting potential therapeutic targets.

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Implication

Experimental findings reveal that PCBP2 mediates olaparib resistance in breast cancer, indicating m6A methylation's impact on PARP1 mRNA stability.

Abstract

Supplementary Table S2: Guide RNAs used for the targeted RNA methylation system.

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Cite This Study

Qi et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcadf https://doi.org/10.1158/0008-5472.30363391

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S1 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
2Table S3 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
3Table S5 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
4Table S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
5Figure S1 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025

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Figure S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
Figure S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
Figure S3 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025