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October 15, 2025

Table S1 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m⁶A Methylation to Stabilize PARP1 mRNA

Zhaochang Qi Lifang He Zemei Xu Xi Luo Likeng Ji Chuqi Lin Armando E. Giuliano Xiaojiang Cui Zihao Deng Jundong Wu Stanley L. Lin Yu Cui

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Key Points

Inhibiting m6A methylation stabilizes PARP1 mRNA, leading to olaparib resistance.
Key evidence indicates that altered methylation significantly affects mRNA levels of PARP1, enhancing resistance effects.
This analysis utilizes supplementary genetic data from Table S1 to assess siRNA and shRNA sequences involved in the process.
Understanding these mechanisms may highlight new therapeutic targets for overcoming drug resistance in breast cancer.

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Implication

Research shows olaparib resistance in breast cancer by inhibiting methylation, suggesting new treatment pathways.

Abstract

Supplementary Table S1: Target sequences of siRNAs and shRNAs

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Cite This Study

Qi et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcb09 https://doi.org/10.1158/0008-5472.30363397

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
2Table S3 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
3Table S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
4Table S5 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
5Figure S1 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025

More related papers

Figure S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
Figure S3 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
Figure S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025