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October 15, 2025

Table S5 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m⁶A Methylation to Stabilize PARP1 mRNA

Zhaochang Qi Lifang He Zemei Xu Xi Luo Likeng Ji Chuqi Lin Armando E. Giuliano Xiaojiang Cui Zihao Deng Jundong Wu Stanley L. Lin Yu Cui

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Key Points

Olaparib resistance is mediated by PCBP2 inhibiting m6A methylation.
PCBP2's action stabilizes PARP1 mRNA, impacting treatment efficacy.
Clinical characteristics were assessed in 10 human BRCA-mutated breast cancer samples.
Understanding this mechanism highlights potential therapeutic targets for breast cancer.

Implication

Observational analysis shows that PCBP2 inhibits m6A methylation, suggesting a link to PARP1 mRNA stability.

Abstract

Supplementary Table S5: Clinical characteristics of 10 human BRCA-mutated breast cancer tissue samples

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Cite This Study

Qi et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcbe0 https://doi.org/10.1158/0008-5472.30363382

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S3 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
2Table S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
3Table S1 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
4Figure S1 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
5Table S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025

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Figure S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
Figure S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
Figure S3 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025