Figure S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m⁶A Methylation to Stabilize PARP1 mRNA

Zhaochang Qi; Lifang He; Zemei Xu; Xi Luo; Likeng Ji; Chuqi Lin; Armando E. Giuliano; Xiaojiang Cui; Zihao Deng; Jundong Wu; Stanley L. Lin; Yu Cui

doi:10.1158/0008-5472.30363403

October 15, 2025Open Access

Figure S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m⁶A Methylation to Stabilize PARP1 mRNA

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Key Points

Depletion of PCBP2 leads to increased degradation of PARP1 mRNA, indicating its role in olaparib resistance.
Lower levels of m6A methylation promote recruitment of the methyltransferase complex to PARP1 mRNA, enhancing decay.
The findings illustrate a critical mechanism that breast cancer cells may exploit to survive olaparib treatment.
Understanding this pathway could illuminate strategies to overcome drug resistance in breast cancer therapies.

Implication

Supplementary analysis demonstrates PCBP2's role in stabilizing PARP1 mRNA in breast cancer, highlighting its impact on treatment resistance.

Abstract

Supplementary Figure S4 supports the Results section titled "Depletion of PCBP2 facilitates m6A methyltransferase complex recruitment and accelerates PARP1 mRNA degradation".

Discussion

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Cite This Study

Qi et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcc00 https://doi.org/10.1158/0008-5472.30363403

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Figure S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m⁶A Methylation to Stabilize PARP1 mRNA

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m⁶A Methylation to Stabilize PARP1 mRNA

Key Points

Implication

Abstract

Discussion

Cite This Study

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