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October 15, 2025

Figure S5 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m⁶A Methylation to Stabilize PARP1 mRNA

Zhaochang Qi Lifang He Zemei Xu Xi Luo Likeng Ji Chuqi Lin Armando E. Giuliano Xiaojiang Cui Zihao Deng Jundong Wu Stanley L. Lin Yu Cui

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Key Points

Olaparib resistance is mediated by PCBP2 that stabilizes PARP1 mRNA, enhancing treatment evasion.
YTHDF2's regulation impacts PARP1 mRNA stability directly linked to olaparib sensitivity in breast cancer.
Observational analysis of m6A methylation provides insights into the mechanisms underlying therapeutic resistance.
Findings highlight the importance of understanding mRNA stability for improving treatment strategies against breast cancer.

Implication

Analysis demonstrates olaparib resistance via m6A methylation in breast cancer, indicating PCBP2's pivotal role.

Abstract

Supplementary Figure S5 supports the Results section titled "YTHDF2-dependent regulation of PARP1 mRNA stability modulates olaparib sensitivity".

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Cite This Study

Qi et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcb12 https://doi.org/10.1158/0008-5472.30363400

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S1 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
2Figure S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
3Figure S3 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
4Figure S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
5Table S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025

More related papers

Table S3 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
Table S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
Table S5 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025