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October 15, 2025Open Access

Table S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m⁶A Methylation to Stabilize PARP1 mRNA

Zhaochang Qi Lifang He Zemei Xu Xi Luo Likeng Ji Chuqi Lin Armando E. Giuliano Xiaojiang Cui Zihao Deng Jundong Wu Stanley L. Lin Yu Cui

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Key Points

PCBP2 inhibition of m6A methylation enhances PARP1 mRNA stability, leading to increased olaparib resistance.
Key findings reveal that targeting m6A methylation could improve treatment responses in breast cancer patients.
The research utilizes supplementary sequences to construct pcDNA3.1-PARP1 mRNA, highlighting molecular pathways involved.
This study suggests that therapeutic strategies must account for PARP1 regulation to overcome olaparib resistance.

Implication

Research shows that PCBP2 mediates olaparib resistance in breast cancer, indicating its role in m6A methylation inhibition.

Abstract

Supplementary Table S4: Sequences of primers used for pcDNA3.1-PARP1 mRNA construction

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Cite This Study

Qi et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcc7d https://doi.org/10.1158/0008-5472.30363385

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S3 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
2Table S1 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
3Table S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
4Figure S1 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
5Figure S3 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025

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Figure S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
Table S5 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
Figure S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025