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October 15, 2025Open Access

Table S3 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m⁶A Methylation to Stabilize PARP1 mRNA

Zhaochang Qi Lifang He Zemei Xu Xi Luo Likeng Ji Chuqi Lin Armando E. Giuliano Xiaojiang Cui Zihao Deng Jundong Wu Stanley L. Lin Yu Cui

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Key Points

PCBP2 mediates olaparib resistance by inhibiting m6A methylation to stabilize PARP1 mRNA, impacting breast cancer treatment.
Key evidence shows that modulation of m6A methylation significantly alters PARP1 levels in breast cancer cell lines.
The study utilized quantitative RT-PCR to assess mRNA levels of PARP1 and explore the regulation by PCBP2 in cancer cells.
Understanding this mechanism could help develop strategies to overcome olaparib resistance in breast cancer therapies.

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Implication

Analysis reveals PCBP2 inhibits m6A methylation to stabilize PARP1 mRNA, suggesting potential resistance mechanisms in breast cancer.

Abstract

Supplementary Table S3: Primers used for quantitative RT-PCR

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Cite This Study

Qi et al. (2025) studied this question.

synapsesocial.com/papers/68f199c5de32064e504dcd70 https://doi.org/10.1158/0008-5472.30363388

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Table S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
2Table S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
3Table S1 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
4Table S5 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
5Figure S1 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025

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Figure S2 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
Figure S3 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025
Figure S4 from PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m<sup>6</sup>A Methylation to Stabilize PARP1 mRNA2025