Prospective case series reports improved hydration and satisfaction in women following dual-product HA injections, indicating effective rejuvenation.
Background: Age-related earlobe changes such as volume loss, wrinkling, and reduced projection can subtly affect facial balance. Hyaluronic acid (HA) fillers restore volume, whereas low-viscosity HA “skin boosters” improve hydration and texture. Combining these products may enhance rejuvenation outcomes. The objective of this study was to evaluate the safety and short-term outcomes of a dual-product HA injection protocol targeting both volume and skin quality in moderately aged earlobes. Methods: In this prospective case series, 30 women (aged 40–65 y) received a standardized, 3-step treatment: (1) deep volumization with cross-linked HA via 22G cannula, (2) superficial skin booster using 30G needle, and (3) optional refinement with high G′ HA via 27G needle. Assessments at baseline, 1 month, and 3 months included skin hydration (Corneometer), patient satisfaction (5-point Likert), procedural pain (visual analog scale), and adverse events. Results: Hydration improved significantly (45.2% at baseline to 54.5% at 3 mo; P < 0.001), as did satisfaction scores (2.3–4.7; P < 0.001). Pain was minimal (visual analog scale score 2.4), and adverse events were limited to mild swelling (15%) and bruising (10%). Conclusions: Layered HA injections targeting both structural and superficial compartments seem to be safe, well tolerated, and associated with meaningful aesthetic improvements. Further studies are warranted.
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Adel et al. (2025) studied this question.
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