What question did this study set out to answer?

To investigate the association between whole blood viscosity and chronic complications in sickle cell disease.

December 8, 2025Blood

Higher baseline whole blood viscosity is associated with chronic SCD complications

View Full Paper

Ask AI

Bookmark

Authors

JKJedrzej KonarkowskiEmory University JWJon WadeUniversity of Oxford VSVivien SheehanEmory University

Discussion

Member takes

Implication

Prospective study reveals whole blood viscosity associates with hemolysis complications in sickle cell disease patients, suggesting new risk assessment biomarkers.

Key Points

To investigate the association between whole blood viscosity and chronic complications in sickle cell disease.
Collected blood samples from 540 adults with sickle cell disease
Assessed whole blood viscosity using viscometry at different shear rates
Performed chart reviews to gather complication data
16 individuals developed complications like priapism or pulmonary embolism post-measurement.
Lower hemoglobin-hematocrit ratio associated with complications in venous shear state.
Higher reticulocyte counts and reduced hemoglobin levels observed in individuals with complications.

Cite This Study

Konarkowski et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc22 https://doi.org/10.1182/blood-2025-7855

View Full Paper

Ask AI

Bookmark

Implication

Prospective study reveals whole blood viscosity associates with hemolysis complications in sickle cell disease patients, suggesting new risk assessment biomarkers.

Higher baseline whole blood viscosity is associated with chronic SCD complications

Discussion

Member takes

Implication

Key Points

Cite This Study

Higher baseline whole blood viscosity is associated with chronic SCD complications

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider