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December 8, 2025BloodOpen Access

Clonal T-large granular lymphocytes (LGL) in chronic relapsing-remitting and refractory immune thrombocytopenia

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Authors

IWIlene WeitzUniversity of Southern California

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Implication

Prospective study identifies T-LGL lymphocyte role in chronic immune thrombocytopenia, suggesting new monitoring needs.

Key Points

  • To explore the presence and significance of clonal T-large granular lymphocytes in patients with chronic immune thrombocytopenia (ITP).
  • Conducted prospective study on chronic ITP patients using flow cytometry and blood smear analysis on Cellavision.
  • Sent samples for T-cell receptor gene rearrangement if T-LGL lymphocyte presence was confirmed.
  • Monitored LGL population changes through regular follow-up and analysis.
  • Identified 11 patients with CD8, CD57+ clonal LGL lymphocytes.
  • Average patient age was 61 years, with a mean duration of ITP of 17 years.
  • 7 patients showed increased T-LGL populations during follow-up; some patients achieved long-term stability with T-cell directed therapies.

Cite This Study

Ilene Weitz (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236de98https://doi.org/10.1182/blood-2025-3036
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Also Consider

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  1. 1Features of the subpopulation composition and functional activity of peripheral blood lymphocytes and monocytes in patients with primary autoimmune thrombocytopenia2025 · 1 citations
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  3. 3Flow cytometric analysis of T-cell subsets and platelet surface markers in patients with immune thrombocytopenia: a case-control study2026
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  5. 5Single-cell dissection of pathogenic T-cell response to tacrolimus in immune thrombocytopenia2025