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December 8, 2025BloodOpen Access

Impact of preexisting chronic obstructive pulmonary disease on in-hospital outcomes in first-time acute chest syndrome: A nationwide analysis, 2016–2022

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Authors

TOTobechukwu OkobiSJStephen Jesmajian

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Overview

Retrospective cohort study shows COPD impacts hospitalization and mortality in sickle cell disease patients, indicating potential recognition benefits.

Key Points

  • Investigate the impact of preexisting COPD on in-hospital outcomes for patients with acute chest syndrome (ACS).
  • Retrospective cohort study utilizing the HCUP-NIS database (2016-2022)
  • Identified patients with first-time ACS and preexisting COPD using ICD-10 codes
  • Analyzed in-hospital mortality, length of stay, resource utilization, and interventions
  • Among 36,449 first-time ACS patients, 2.28% had preexisting COPD
  • Patients with COPD experienced shorter length of stay by 1.24 days and reduced hospital charges by $28,064.57
  • No significant differences in red blood cell transfusion rates, but higher odds of requiring hemodialysis were noted.

Cite This Study

Okobi et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e209https://doi.org/10.1182/blood-2025-4444
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In-hospital outcomes of patients admitted due to first-time acute chest syndrome with preexisting pulmonary embolism: A nationwide analysis 2016-20222025
  2. 2Prevalence and Prognosis of Chronic Obstructive Pulmonary Disease Among 8167 Middle Eastern Patients With Acute Coronary Syndrome2010 · 68 citations
  3. 3The Impact of Sickle Cell Disease on Acute Coronary Syndrome and PCI Outcomes: A Retrospective Observational Study2024 · 3 citations
  4. 4Clinical and laboratory findings in adults with sickle cell disease which increase risk for severe acute chest syndrome2025
  5. 5Impact of obesity on inpatient outcomes in patients hospitalized with acute chest syndrome2025