Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Salvage allogeneic hematopoietic stem cell transplantation conditioning regimens for relapsed/refractory acute leukemia: Efficacy of radiotherapy combined with CLAG vs FLAG

View Full Paper
Ask AI
Bookmark
Share

Authors

XMXiao‐Yong ManJWJingbo WangCCChun Chang

Discussion

Loading...

Member takes

Overview

Retrospective analysis shows radiotherapy with CLAG improves outcomes in acute lymphoblastic leukemia, suggesting better survival.

Key Points

  • To evaluate the efficacy of different conditioning regimens in allogeneic hematopoietic stem cell transplantation for relapsed/refractory acute leukemia.
  • Retrospective analysis of 233 patients with relapsed/refractory acute leukemia (2015-2023)
  • Patients treated with conditioning regimens of radiotherapy combined with CLAG or FLAG
  • Outcomes measured were overall survival, disease-free survival, cumulative incidence of relapse, and non-relapse mortality.
  • 10-year overall survival was 32.9%
  • 10-year disease-free survival was 29.6%
  • No significant differences in outcomes between CLAG and FLAG regimens
  • In ALL patients, TBI/CLAG trended towards better OS and lower NRM compared to TBI/FLAG.

Cite This Study

Man et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e3eahttps://doi.org/10.1182/blood-2025-2428
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Efficacy and safety of FLAG and CLAG regimens (Replacing Cyclophosphamide) in conditioning for allogeneic hematopoietic stem cell transplantation in relapsed/refractory malignant hematologic diseases2025
  2. 2Addition of thiotepa to total body irradiation-based conditioning in allogeneic hematopoietic stem cell transplantation for relapsed/refractory acute leukemia and lymphoma: a propensity score-matched retrospective study2026
  3. 3Outcome of allogeneic hematopoietic cell transplantation in adult acute lymphoblastic leukemia patients who underwent myeloablative TBI-free conditioning regimen2025 · 1 citations
  4. 4Allogeneic HSCT for consolidation in pediatric refractory or relapsed ALK-positive anaplastic large cell lymphoma2026
  5. 5Efficacy of thiotepa-containing conditioning regimens and mucositis burden in allogeneic HSCT for relapsed/refractory acute leukemia with extramedullary disease2025